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WEDNESDAY, APRIL 23 TECH EXPO • 8:30 am - 12 pm Explore available next generation screening platforms as presented by sequencing leaders. An unparalleled opportunity to compare and contrast these next generation sequencing platforms to best suit your research needs. Sponsored Seminars Hosted by: 454/Roche Title and Speaker to be Announced True Single Molecule Sequencing: Current Research and Our Path to the $1000 Genome Patrice M. Milos, Ph.D., Vice President and Chief Scientific Officer, Helicos Helicos has developed a novel genetic analysis platform to efficiently and accurately determine the direct sequence of individual DNA molecules. Simplicity in sample preparation, development of novel surfaces, chemistry to enable incorporation of single nucleotides into DNA strands and finally the visualization of fluorophore addition to monitor real time sequencing by synthesis has been achieved. This platform will provide the opportunity for researchers to interrogate the genome on a new scale and provides a path to sequence individual genomes at a cost to make integration of genome knowledge and healthcare possible. To demonstrate the current power of the HelicosTM platform we will discuss the use of the True Single Molecule Sequencing Technology (tSMSTM) for candidate gene resequencing, RNA measurements and miRNA analyses. Illuminating the Genome Abizar Lakdawalla, Ph.D., Senior Product Manager, Sequencing Applications, Illumina The Illumina Genome Analyzer, based on the Solexa massively parallel sequencing-by-synthesis technology, is being utilized for a broad set of functional genomics applications including chromosomal re-arrangements to single nucleotide variations, variation in DNA methylation, whole transcriptiome analysis, small RNA analysis, digital gene expression, DNA-protein, and DNA-RNA interaction analysis. Details on the current state of the technology as well as a summary of chromosomal resequencing studies, whole genome epigenetic changes, tissue-specific mRNA splice variants and 5-UTRs, microRNAs and DNA-protein interaction studies will be presented. Challenge Team Discussion Host: Kevin Davies, Ph.D., Editor-in-Chief, Bio-IT World

DON’T MISS! CO-LOCATED EVENTS Next Generation Sequencing Platforms, Applications, and Case Studies April 23-24 Platforms, Applications, and Case Studies The emergence of several next generation sequencing platforms has not only stimulated growth but created excitement within the basic and biomedical research community. The potential applications are as endless as the numbers of samples to analyze. However, the implementation of any new technology is a balancing act of cost-quality-quantity. Cambridge Healthtech Institute’s Second Annual Next Generation Sequencing provides an unparalleled opportunity to compare and contrast next generation sequencing platforms to best suit your research needs. The Challenge of Antibacterial Drug Development April 23- 24