TABLE OF CONTENTS

CHAPTER 1 EXECUTIVE SUMMARY 3
Scope of the analysis 3
Datamonitor insight into the cardiovascular market 3
Related reports 5
Upcoming reports 6

CHAPTER 2 MARKET OVERVIEW AND DYNAMICS 13
Seven major markets 13
Regional markets 16
US 16
Japan 17
Five major EU markets 18
Cardiovascular and metabolic markets by disease area 19
Seven major markets 19
Regional markets 21
US 21
Japan 23
Five major EU market 24
Disease focus by mechanism of action 33
Diabetes 34
US 36
Japan 38
Five major EU markets 40
Dyslipidemia 42
US 44
Japan 46
Five major EU markets 48
Hypertension 51
US 53
Japan 55
Five major EU markets 57
Thrombosis 59
US 61
Japan 63
Five major EU markets 65

CHAPTER 3 MARKET FORECASTS 68
Seven major markets 68
Regional markets 72
US 72
Japan 74
Five major EU markets 75
Cardiovascular and metabolic market by disease area 76
Seven major markets 76
Table of Contents
Regional markets 78
US 78
Japan 79
Five major EU markets 80
Disease focus by mechanism of action 89
Diabetes 89
US 91
Japan 93
Five major EU markets 95
Dyslipidemia 97
US 99
Japan 100
Five major EU markets 102
Hypertension 103
US 104
Japan 106
Five major EU markets 107
Thrombosis 109
US 111
Japan 112
Five major EU markets 113

CHAPTER 4 MARKET ANALYSIS 116
Table of Contents
Commercial Insight: Cardiovascular and metabolic market overview DMHC2540
© Datamonitor (Published 01/2010) Page 6
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Leading cardiovascular and metabolic brands 116
Leading cardiovascular and metabolic active agents 119
Company portfolio assessment 123
The top 10 cardiovascular and metabolic companies, 2008 123
Pfizer 123
Sanofi-Aventis 125
Merck-Schering-Plough 127
Novartis 131
Bristol-Myers Squibb 132
Takeda 133
AstraZeneca 134
Novo Nordisk 136
Daiichi Sankyo 136
Abbott 138
Geographical distribution 138
Company vulnerability 140
The forecast top 10 cardiovascular and metabolic companies, 2005–2018 143
Bibliography 147

APPENDIX A – MARKET ASSUMPTIONS 148
Data definitions, limitations and assumptions 148
Standard units 148
Japanese market data 148
Table of Contents
Commercial Insight: Cardiovascular and metabolic market overview DMHC2540
© Datamonitor (Published 01/2010) Page 7
This report is a licensed product and is not to be photocopied
Derivation of sales forecasts and pricing trends 148
Forecasts 149
Forecast methodology 149
Datamonitor reports 149

APPENDIX B –MARKET FORECAST DATA 151
Seven major markets 151
Regional markets 162
US 162
Japan 169
Five major EU markets 174
France 183
Germany 189
Italy 196
Spain 202
UK 208
APPENDIX C 213
Report methodology 213
About Datamonitor 213
About Datamonitor Healthcare 213
Disclaimer 217