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Articles from Issue 117 August 2010:

• Diabetes Pipeline: Intense Activity to Meet Unmet Need
• Epigenetic Drug & Diagnostic Pipelines: DNA Methylation, HDAC Inhibitors, and Emerging New Targets

• MicroRNAs miR-17 and miR-20a Inhibit T Cell Activation Genes and Are Under-Expressed in MS Whole Blood

Articles from Issue 116 July 2010:

• Drug Repositioning: Extracting Added Value from Prior R&D Investments
• Epigenetic Drug & Diagnostic Pipelines: DNA Methylation, HDAC Inhibitors, and Emerging New Targets

• Novel Antibodies

Articles from Issue 115 June 2010:

• Combination Drug/Diagnostics: Fueling Growth of Personalized
• Epigenetic Drug & Diagnostic Pipelines: DNA Methylation, HDAC Inhibitors, and Emerging New Targets

• Ontologies in Quant Biology

Articles from Issue 114 May 2010:

• Vaccine-Autism War

Articles from Issue 113 April 2010:

• Combination Drug/Diagnostics: Fueling Growth of Personalized
• Cloud Computing in Life Sciences R&D

• Homeodomain Interacting Protein Kinase

Articles from Issue 112 March 2010:

• Animal Models for Therapeutic Strategies
• Kinase Therapeutics: Pipeline Assessment and Commercial Prospects

• Rating Core Labs Survey

Articles from Issue 111 February 2010:

• Strategic Alliances: Synergistic Path to Value Creation
• Kinase Therapeutics: Pipeline Assessment and Commercial Prospects

• Beyond EDC: Resolving Data-entry Challenges faced by Electronic Data Capture Systems in Clinical Trials

Articles from Issue 110 January 2010:

• Strategic Alliances: Synergistic Path to Value Creation
• Inflammatory Disorders: Therapies That Suppress or Balance the Immune Response

• A Proteomic Approach

Articles from Issue 109 December 2009:

• Inflammatory Disorders: Therapies That Suppress or Balance the Immune Response
• Multiplex Assays: Evolving Technologies, Applications, and Future Directions

• Smarter Studies DATA ANALYSIS SOLUTIONS DA-SOL GmbH

Articles from Issue 108 November 2009:

• Immunotherapies and Vaccines for Nontraditional Indications
• Next-Generation Sequencing: Solving the Genome

• Molecular Genomic Approaches to Infectious Diseases in Resource-Limited Settings

Articles from Issue 107 October 2009:

• Monoclonal Antibodies: Pipeline Analysis and Competitive Assessment
• Immunotherapies and Vaccines for Nontraditional Indications

• Site Gripes and Solutions for EDC

Articles from Issue 106 September 2009:

• Ion Channel Modulator Pipelines: Targets and Agents in Development
• Next-Generation Sequencing: Solving the Genome

• Understanding The 505(b)(2) Approval Pathway

Articles from Issue 105 August 2009:

• Data Mining In Drug Development and Translational Medicine
• Bioinformatics and Computational Biology: Bottlenecks and Options

• Strategic Opportunities & Directions in Molecular Diagnostics

Articles from Issue 104 July 2009:

• Next-Generation Sequencing: Solving the Genome
• Pharmacogenomics: Delivering on the Promise - An Interview with Dr. Allen Roses

• Answers to your questions about cell culture and a sneak preview of what’s to be discussed at The Bioprocessing Summit

Articles from Issue 103 June 2009:

• Bioinformatics and Computational Biology: Bottlenecks and Options
• Approaches to Reducing Phase II Attrition - an interview with Charles Gombar, PhD

• A Broken Trust: Lessons from the Vaccine–Autism Wars

Articles from Issue 102 May 2009:

• Medicinal Chemistry for Drug Discovery: Significance of Recent Trends
• Approaches to Reducing Phase II Attrition

• Rare Variants via Sequencing

Articles from Issue 101 April 2009:

• Medicinal Chemistry for Drug Discovery: Significance of Recent Trends
• Direct-to-Consumer Genetic Testing: Business Prospects in the United States

• A Compendium of Potential Biomarkers of Pancreatic Cancer

Articles from Issue 100 March 2009:

• Direct-to-Consumer Genetic Testing: Business Prospects in the United States
• An Interview with Dietrich Stephan, PhD

• Mutation Patterns in the Human Genome: More Variable Than Expected

Articles from Issue 99 February 2009:

• Molecular Diagnostics: A Dynamic and Rapidly Broadening Market
• An Interview with Matt Winkler, Ph.D

• New Directions for Personalized Medicine

Articles from Issue 98 January 2009:

• Conducting Clinical Trials in Europe: An Insider’s Analysis
• Neurodegenerative Diseases: Next-Generation Drugs for Four Major Disorders

• Converging on the Origins of Axonal Ion Channel Clustering

Articles from Issue 97 December 2008:

• Biomedical Imaging: From Drug Target Discovery to Medical Diagnostics

• Stem Cells Come of Age

• Safety and Immunogenicity of a Recombinant Plasmodium falciparum AMA1 Malaria Vaccine Adjuvanted with AlhydrogelTM, Montanide ISA 720 or AS02

Articles from Issue 96 November 2008:

• Stem Cells Come of Age

• Immunotherapies and Vaccines for Cancer and Infectious Diseases

• A Computational Model for Understanding Stem Cell, Trophectoderm and Endoderm Lineage Determination

Articles from Issue 95 October 2008:

• Obesity Drug Pipeline: Developing Therapies for a Complex Disease

• GPCRs: Dawn of a New Era?

• Full-Service EDC as an Alternative to Outsourcing

Articles from Issue 94 September 2008:

• Strategic Management of Resources and Portfolios: Structuring Risk to Maximize Opportunity in Pharmaceutical R&D

• A Seriation Approach for Visualization-Driven Discovery of Co-Expression Patterns in Serial Analysis of Gene Expression (SAGE) Data

Articles from Issue 93 August 2008:

• Strategic Management of Resources and Portfolios: Structuring Risk to Maximize Opportunity in Pharmaceutical R&D
• Cancer Biomarkers: Adoption Is Driving Growth

• Nonnegative Matrix Factorization: An Analytical and Interpretive Tool in Computational Biology

Articles from Issue 92 July 2008:

• Antibiotic R&D: Resolving the Paradox between Unmet Medical Need and Commercial Incentive
• Blood-Brain Barrier: Bridging Options for Drug Discovery and Development

• Starting Over: The Search for Endogenous NKT Cell Ligands

Articles from Issue 91 May 2008:

Articles from Issue 90 May 2008:

Articles from Issue 89 April 2008:

Articles from Issue 88 March 2008:

• Epigenetics: Rolling with the Market
• Epigenetics: Technologies, applications, and the Commercial Landscape
• Impact of Personalized Medicine MDx tests on Oncology Therapeutics

Articles from Issue 87 February 2008:

• Molecular Imaging in Drug R&D and Medical Practice: Technologies, Applications, Markets

• Molecular Imaging: A Detailed Discussion
• Exploration of Small RNA's

Articles from Issue 86 January 2008:

• The Intracacies of the Ophthalmological Therapeutics Market

• Ophthmalmological Therapeutics: A Niche, But Highly Profitable Market
• A Functional Genomic Yeast Screen to Identify Pathogenic Bacterial Proteins

Articles from Issue 85 December 2007:

• A Rapidly Shifting Landscape for Molecular Diagnostics

• Outlook for Predictive Safety Technologies
• Recombinant Interleukin-24 Lacks Apoptosis-Inducing Properties in Melanoma Cells

Articles from Issue 84 November 2007:

• MAbs in Development: Cardiovascular Diseases

• A Major Shift in the Monoclonal Antibodies Market
• New Approaches to Filling the Gap in Tuberculosis Drug Discovery

Articles from Issue 83 October 2007:

• Backup Compound Strategies and Tactics: An Interview with David Lester, PhD

• Backup Compound Strategies: Best Practices for Reducing Phase II Risk
• Induction of BIM Is Essential for Apoptosis Triggered by EGFR Kinase Inhibitors in Mutant EGFR-Dependent Lung Adenocarcinomas

Articles from Issue 82 September 2007:

• Going Forward with Adaptive Clinical Trials: An Interview with Jay Herson, PhD

• Adaptive Clinical Trials: Innovations in Trial Design, Management, and Analysis
• A New Human Genome Sequence Paves the Way for Individualized Genomics

Articles from Issue 81 August 2007:

• Advancing to the Next Generation in DNA Sequencing Technology: An Interview with Tony Smith, PhD

• Next-Generation Sequencing: Scientific and Commercial Implications of the $1000 Genome
• Aging Hematopoietic Stem Cells Decline in Function and Exhibit Epigenetic
  Dysregulation

Articles from Issue 80 July 2007:

• Advancing the Development of Disease-Related Biomarkers,  CHI Insight Pharma Reports

• Disease-Related Biomarkers: Their Potential in Patient Screening, Prognosis, and Stratification, CHI Insight Pharma Reports
• Development of histone deacetylase inhibitors for cancer treatment

Articles from Issue 79 June 2007:

• High Content Analysis: Technologies, Applications, Market Analysis,  CHI Insight Pharma Reports

• A Third-party HCA Software Provider’s Perspective, CEO of Nautilus Biotech
• Epigenetic gene regulation: early environmental exposures

Articles from Issue 78 May 2007:

Articles from Issue 77 April 2007:

• Metabolic and Inflammatory Disease R&D: An assessment of 5 highly promising therapeutic classes

• Metabolic and Inflammatory Disease R&D: An assessment of 5 highly promising therapeutic classes
• Drug-Induced Torsade de Pointes and Implications for Drug Development

Articles from Issue 76 March 2007:

• Transcriptional profiling of multiple sclerosis: towards improved diagnosis and treatment

• PEGylation: Changing the Landscape of Protein Drug Delivery

• Delivery Technologies for Therapeutic Proteins: Assessment and Outlook

Articles from Issue 75 February 2007:

Articles from Issue 74 January 2007:

• Genome-based biomarkers for adverse drug effects, patient enrichment and prediction of drug response, and their incorporation into clinical trial design
• CANCER IMMUNOTHERAPIES AND VACCINES: PIPELINE ANALYSIS AND COMPETITIVE DYNAMICS

Articles from Issue 73 December 2006:

• Standard operating procedures for planning and implementation of Biomarkers
  An Interview with Claudio Carini, MD, PhD, Vice President, Translational Medicine, Development & Regulatory ServicesMDS Pharma Services

• CHA Advances Reports
  Outlook for Predictive Safety Technologies

Articles from Issue 72 November 2006:

• A Model of Translational Medicine for Neurodegeneration Diseases

• The Challenges of Developing a Novel-Acting Agent for Alzheimer’s Disease

Articles from Issue 71 October 2006:

• The era of ErbB-receptor-targeted therapies:
  advances toward personalized medicine

• The Challenges of Developing a Novel-Acting Agent for Alzheimer’s Disease

Articles from Issue 70 September 2006:

• Proteomics: Current State and Future Directions
  An interview with Roger Brent, PhD

• Biomarkers for development of cancer vaccines
  Mike Whelan, Graham Ball, Chris Beattie & Angus Dalgleish

Articles from Issue 69 August 2006:

• Nucleic acid quantification and disease outcome prediction in colorectal cancer

• Antiviral Therapeutics: An Interview with Dr. Michael G. Cordingley

Article from Issue 68 July 2006:

• Multiplex Assays: An Interview with Brian Edmonds, Principal Investigator, Integrative Biology/Global External Research and Development, Eli Lilly & Co.

Article from Issue 67 June 2006:

• Kinase Therapeutics: An Interview with Tony Hunter, PhD Professor, Molecular and Cell Biology Laboratory Salk Institute for Biological Studies

Article from Issue 66 May 2006:

• The Growth of Multiplex Thinking: An Interview with Brian Edmonds of Eli Lilly

Article from Issue 65 April 2006:

• Oncogene Science Pioneers Cancer Drug-Diagnostic Combinations: Walter P. Carney Discusses Recent Developments and Collaborations

Article from Issue 64 March 2006:

• The Growth of Multiplex Thinking: An Interview with Brian Edmonds of Eli Lilly

Article from Issue 63 February 2006:

• Applying Pharmacogenomics to Cancer Drug Development:
  An Interview with Nicholas C. Dracopoli, Ph.D., of Bristol-Myers Squibb 

Articles from Issue 62 January 2006:

• Importance of Rapid Testing to Combat the Global Threat of Bird Flu

• Emerging Opportunities in Clinical Genomics: An Interview with Charles Cantor of SEQUENOM

Articles from Issue 61 December 2005:

• RNAi Therapeutics: From Bench to Bedside
  An Interview with Dr. Barry Polisky of Sirna Therapeutics

Articles from Issue 60 November 2005:

• Gene Expression as a Toxicological Screening Tool

• Challenges to Molecular Diagnostics Will Yield Growth Opportunities for New and Improved Tests 

Articles from Issue 59 October 2005:

• Clinical Application of Phage Display Technologies

• DNA STAT: the ability to perform clinical analysis in real time

Article from Issue 58 September 2005:

• Cancer Diagnostics Market Advances with New Technologies and Innovative Applications: An Interview with Gary Schweikhardt of Epigenomics

Article from Issue 57 August 2005:

• Pharmacodiagnostics and the Future of Personalized Medicine: An Interview with Dr. Walter P. Carney of Oncogene Science

Article from Issue 56 July 2005:

• The Nutrigenomics Business Landscape: An Interview with Jose Ordovas of Tufts University Human Nutrition Research Center

Articles from Issue 55 June 2005:

• Applicability of Biomarkers in the Early Diagnosis of Prostate Cancer

• In Vitro Cardiovascular Diagnostics-Trends and Implications: An Interview with Hans-Juergen Loyda of Roche Diagnostics

Articles from Issue 54 May 2005:

• Biomarkers in Clinical Development:
  Implications for Personalized Medicine and Streamlining R&D

• Biomarker identification in neurologic diseases:
  Improving diagnostics and theapeutics 

Articles from Issue 53 April 2005:

• Nanobiosensors and molecular diagnostics:
  a promising partnership

• 2015: Strategic Considerations for the U.S. Pharmaceutical Industry

Articles from Issue 52 March 2005:

• New Strategies in Neurotherapeutic Drug Development: An Interview with Raymond Bartus of Ceregene

• Diagnostics in Cancer Drug Development

Articles from Issue 51 February 2005:

Articles from Issue 50, January 2005:

• Overcoming the Barriers to CNS Drug Discovery: An Interview with Wendell Wierenga of Neurocrine Biosciences

• Advancements in Predictive Toxicology Will Play an Increasingly Significant Role in Drug Development: An Interview with Thomas J. Colatsky of Icoria

Articles from Issue 49, December 2004:

Articles from Issue 48, November 2004:

• The Monoclonal Antibody Business Landscape

• P450 Stuctures and Oxidative Metabolism of xenobiotics

Articles from Issue 47, October 2004:

• PET and the role of in vivo molecular imaging in personalized medicine

• Monoclonal Antibody-Based Products Poised for Continued Growth as Drug Developers Focus on Bringing Improved Products to Market

Articles from Issue 46, September 2004:

• The role of investigative molecular toxicology in early stage drug development

• Ligands of the Melanocortin receptors, 2002-2003 update